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In order to develop more specific and less toxic inhibitors, there have been efforts to utilize interactions in the region of the active site of GGT that binds the cysteinylglycine moiety of GSH (13, 17)

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(2009) Structure, function, and post-translation regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Beyond A clearance, astrocytes also display resilience to proteotoxic stress by activating protective pathways, including glutathione synthesis and heat shock protein expression