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Transdermal patches containing JAK inhibitors or tacrolimus are already undergoing trials

In some cases of long-term severe deficiency, healing of the nerve damage may be extremely slow, requiring maintenance of B12 levels for months to achieve optimal recovery

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doi: 10.3390/ijms241512133 85 EckfeldCHulerDSchoepsBHermannCDKrgerA

Iron regulatory proteins (IRPs) are critical for maintaining iron homeostasis, as they control the expression of genes involved in iron absorption, storage, and export by interacting with iron response elements (IREs) (60)