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121 Mutations in the progranulin gene, GRN , which cause a genetic familial FTD, downregulate expression of EAAT2 astrocyte glutamate transporter, which mediates synaptic degeneration

Similarly, Gadzhimagomedova et al

Ferroptosis is a process in which iron catalyzes the peroxidation of unsaturated fatty acid-rich lipids, with ferrous iron or lipoxygenase acting as catalysts and ultimately resulting in cellular demise

doi: 10.1200/JCO.2015.63.4691 50 NagpalSHarshGRechtL

The liver-eye axis Hepatokines, such as FGF21, factor H-related protein 4 (FHR-4), and hepcidin, also mediate the crosstalk from the liver to the eyes [Figure 11]

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