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These adaptive strategies have demonstrated in ( Figure 3B ) the feasibility of non-continuous dosing schedules in selected clinical contexts

Pro-inflammatory cytokines such as IL-1, IL-6, IFN-, TNF- and pro-inflammatory transcription factors: NF-B (202), AP-1 (203), NFAT (204), STAT1 (205), and HIF-1 (206) induce the expression of iNOS and NO production (202)