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One hypothesis that can account for the observation of an increased risk for asthma attacks with LABA monotherapy is that patients may feel better when taking long-acting beta agonists, and as a result take either lower doses of inhaled corticosteroids, or no corticosteroids at all

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104 This is consistent with observations in model mice

The pathogenesis of LDDD involves age-related (Ohnishi et al., 2018) or injury-induced (Wang et al., 2023) degeneration of the intervertebral discs (IVDs)