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Moreover, BaP metabolite BPDE could induce DNMT3a binding to the promoters of related tumor suppressor genes, which resulted in the aberrant methylation of retinoic acid receptor-2 (RAR-2) in human esophageal cancer cells, and BPDE reduced DNMT3b expression [153]

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Taken together, for rapid and precise detection and/or treatment of APAP-associated idiosyncratic DILI, it is necessary to assess the causality by the RUCAM score

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