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In terms of new research avenues in the NAD + field, it is also emerging that apart from its effects on the mitochondria, NAD + plays a multitude of roles in regulating both metabolic and non-metabolic processes

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Initial evidence for this was obtained by Bitterman et al., who demonstrated that NAM could inhibit yeast Sir2 and human SIRT1 noncompetitively in vitro [61]

93 Consistent with these data, JNK inhibitors were shown to prevent nitrotyrosine staining and effectively protect against APAP-induced liver injury