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HG-induced iron overload generates hydroxyl radicals, causing mitochondrial membrane potential (MMP) depolarization, mtDNA damage, and dysfunction ( 3.3.5 Antioxidant proteins as potential therapeutic targets for ferroptosis in DN Ferroptosis in DN is governed by a core network of antioxidant proteins, with Nrf2 as the master transcriptional regulator

doi: 10.1002/j.1552-4604.2002.tb05998.x

Age-associated decrease in the rate of diffusion of glutathione to the lens nucleus is likely to be part of the reason for this increased susceptibility

& Singh, I

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Images were pseudocolored with the ratio of fluorescence excited at 407 nm and 482 nm