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Adequate micronutrient supplementations are indicated, in addition to supplemental antioxidants, in conditions of suspected mitochondrial dysfunction and periods of oxidative stress

Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, et al

The exposure to LPS was associated with increased number of total cells (1.9x10 5 cells, 95% CI: 0.9x10 5 to 3.0x10 5 cells), whereas there were slightly lower numbers of total cells in the LPS-exposed mice that also received high-dose CB (-0.5x10 5 cells, 95% CI: -1.5x10 5 to 0.6x10 5 cells) relative to the LPS-exposed mice (Table 1)

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The authors further demonstrated the role of TLR-4 in mediating brain injury by generating mice lacking TLR-4 in microglia