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Furthermore, heavy drinkers exhibit elevated levels of peripheral inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP), which cross the bloodbrain barrier to promote neuroinflammationa shared pathway in both ethanol-induced neurotoxicity and depression (Adams et al

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The antioxidant system is important in the re-establishment of oxidative homeostasis, on the contrary, may increase oxidative stress conditions and lead to cell death, senile aging, and disease decompensation