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Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes

PubMed Central, Lang, Thomas, et al

Quercetin nanoparticles caused fast regeneration of hepatic biomarkers, as well as down-regulation of serum enzyme parameters and a substantial increase in hepatocytes even when administered after toxin-induced hepatic damage

Liver markers, such as alanine transaminase (ALT) and aspartate aminotransferase (AST), as well as kidney markers, including creatinine (CRE) and blood urea nitrogen (BUN), remained within normal ranges, suggesting no hepatic or renal toxicity (Figures 8BE)

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