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This adaptive circuitry enables cancer cells to continuously remodel their metabolic architecture under therapeutic pressure, maintaining ROS balance and promoting survival [34]

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The main pathomechanisms of melasma occurrence through the sun-exposure is depicted in Figure 1

Amlodipine Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle

However, as the diseased state progresses, chronic inflammation causes harmful effects, leading to neurodegeneration (Di Benedetto et al., 2022)

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