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However, among different types of mushroom tyrosinase inhibitors, some inhibitors such as hydroquinone 49 arbutin, kojic acid 15 , 49 , azelaic acid, l-ascorbic acid, ellagic acid and tranexamic acid have been reported as skin-whitening agents in the cosmetic industry but there are a few reports failed to confirm their effect as an agent to lighten skin in clinical trials despite the safety of this compound 5

At 6 months post-therapy, attachment loss (AL), periodontal probing depth (PD), gingival recession (GR), tooth mobility (TM), and bone defect depth (BDD) were examined

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