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Moreover, there is a risk of developing tolerance or dependence on weight loss pills, which may result in reduced efficacy over time or difficulty in maintaining weight loss once the medication is discontinued

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Resistance training, adequate protein intake (1.2-1.6 g/kg/day, adjusted to actual body weight), and consideration of complementary compounds that support lean mass, such as tesamorelin for GH-mediated anabolic support or CJC-1295/Ipamorelin for broader GH optimization, become increasingly important with longer treatment duration

J Pediatr

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