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His appetite improved, and he started to gain back some of his lost body weight

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In light of the primary goals, the secondary endpoints are adequate for claiming or labeling the efficacy of the clinical trial study, and the exploratory and tertiary endpoints provide support for descriptive information [10]

Typical dose-50 mg twice a day up to 100 mg twice a day (lower in older patients and those with diabetes or kidney disease) Statins are also a useful drug to lower testosterone in PCOS

Besides, it further selectively kills lung adenocarcinoma (LUAD) cell lines through an oxidative stress-induced apoptosis mechanism

10.1126/science.276.5309.122 Summary Keywords busulfan, population pharmacokinetics, glutathione S-transferase activity, precision dosing, pediatric transplantation, virtual clinical trial Citation Cao D, Qian X, Wang P, Zheng X, Huang S, Wei Z, Jiang W, Yu L, Jiang X, Yu Y, Mao J and Zhai X (2025) Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation