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Shao YY, Chen PS, Lin LI, Lee BS, Ling A, Cheng AL, et al

Animals treated with CBD showed reduced nigrostriatal degeneration and neuroinflammatory response together with improved motor performance

doi:10.1080/19390211.2025.2483269

Among the most studied agents for this purpose is Erastin, a compound that induces ferroptosis through a distinct mechanism

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval