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In these patients, the clot risk is referring to STROKES

Although the role of L-lactate in exercise, hypoxia, and metabolic diseases has been extensively studied, the physiological and pathophysiological roles of D-lactate remain poorly understood

Using a kinetic assay, the amount of total glutathione was determined by continuously reducing 5,5-dithiobis (2-nitrobenzoic acid) (Sigma-Aldrich) to 5-thio-2-nitrobenzoic acid in the presence of catalytic amount (nmol) of GSH (TNB), and GSH reductase and nicotinamide adenine dinucleotide phosphate (Sigma-Aldrich) regenerated the GSSG (oxidized GSH) that was produced

Mendez, 2019

suggests that multiple amino acid substitutions are introduced to support the peptides stability against enzymatic degradation potentially: (1) Position 2 (Alanine D-Alanine): Introduces a D-form amino acid, which is less susceptible to standard enzymatic breakdown

A.van der HouwenT