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Cambridge, MA, USA: 2023

During primary drying, the ice sublimes under vacuum, leaving behind a nearly dried matrix consisting of disaccharides and proteins, and during secondary drying, the remaining moisture desorbs as the temperature is elevated, resulting in a dry, porous structure known as a lyophilized cake (Matejtschuk 2007

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At the level of the whole cell, one function of homeostatic mechanism(s) is to preserve an overall synaptic drive and avoid excessive input changes, which may lead to runaway activation or complete silencing of a neuron