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Anand S, Rajagopalan S, Mohan R Management of liver hydatid cysts - Current perspectives

Fate Chem

Specifically, gemcitabine stabilizes mutp53 and promotes its phosphorylation at Ser15, mutp53 then induces CDK1 (Cyclin Dependent Kinase 1) and CCNB1 (Cyclin B1) gene expression promoting a hyperproliferation effect and chemoresistance (Fiorini et al., 2015)