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We believe that the main reason for the differences between our results and that of previous reports was the concentration of AM404 (30 M) in our study, which is equivalent to the clinically recommended dosage of acetaminophen (20 mg/kg)

application of Pull-Down application of Pull-Down Verify Known Interactions Pull-down experiments were performed to verify whether there was a direct interaction between the two proteins

Other chemotherapy agents, including 5-FU and its prodrug, capecitabine (Xeloda), cisplatin, paclitaxel, and docetaxel, can also cause cardiotoxicity (Molinaro 2015

Numerous polysaccharides, including D-xylose, D-galactose, L-rhamnose, L-arabinose, D-mannose, and glucuronic acid, are present in gum exudates [48]

Furthermore, we identified dysregulation of the methionine cycle and transsulfuration pathway, leading to severe glutathione (GSH) exhaustion and indirect deactivation of glutathione peroxidase 4 (GPx4), a critical enzyme in preventing ferroptosis

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