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Tetrahydrobiopterin (BH 4 ) eNOS requires several cofactors, such as heme, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), as well as BH 4 for elicitation of full enzymatic activity

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Additionally, mice fed HCD had greater levels of 13(S)-HODE (hydroxyoctadecadienoic acid), while the precursor of 9(S)-HODE (hydroxyoctadecadienoic acid) was higher in LCD-fed mice than in HCD-fed mice (13)