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Elimination of senescence in these old adult livers by AP20187 reduced number of neutrophils as revealed by IHC for myeloperoxidase (MPO), attenuated fat accumulation in Oil red staining, and decreased levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in sera compared to age-matched vehicle-treated controls, indicating that senescence clearance reduced ethanol-induced injury in aging livers

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