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(Reference Naderifar, Gangeh, Mehri and Kazemi33,Reference Kondori, Ghaleh and Hosseini35,Reference Bagheri, Rashidlamir and Ashtary-Larky39,Reference Azizbeigi, Stannard and Atashak40) It should be noted that we made sure that in case of combined intervention, the control group received the same accompanied treatment

In the Ras pathway, Erk1/2 as two mitogen-activated protein kinases to transmit mitotic signals, and the HGF/c-Met signaling pathway phosphorylates and activates Erk1/2 after PHx (Spector et al., 1997