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Examples of promising candidates with different surface charges include positively charged alendronate-loaded chitosan nanoparticles (zeta potential +23.8 mV), which have demonstrated enhanced brain delivery, leading to higher accumulation in the brains of intracerebroventricular-streptozotocin (ICV-STZ)-induced AD-like mice and improved pharmacokinetic profiles compared with free alendronate, suggesting more effective intranasal delivery (Zameer et al., 2021)

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Lift it away from the underlying muscle and bone