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This way, the first reactive toxical specie of oxygen, the superoxide, like in the scheme: 1.7.3 FREE RADICAL Free radical is any spice able of independent existance and which contains one or more electrons unmatched, that is, electrons present individualy in atomic or molecular orbitals (Halliwell and Gutteridge, 1985)

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gut, bones, kidneys) and helps regulate calcium absorption, immune function, insulin sensitivity, and cellular proliferation and differentiation

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FIGURE 5 4.7 Mitochondrial dysfunction Mitochondria, the energy factory of eukaryotic cells, produce energy through the metabolism of lipids, steroids, and proteins, which play a key role in maintaining cellular stability by regulating Ca 2+ levels, maintaining ROS levels, and regulating apoptosis (Nunnari and Suomalainen, 2012)