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Route of administration changes the result: supervised subcutaneous injection of 503A compounded GHK-Cu produces systemic and targeted effects that topical serums cannot replicate

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It is important to note that the majority of this mechanistic research has been conducted in cell culture and animal models, with a significant proportion originating from a single research group

However, patients with dihydrobiopterin deficiency may develop early brain atrophy and intracranial perivascular calcifications [118, 119]

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