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Peer review Peer review information Nature Reviews Neuroscience thanks Tracy Young-Pearse, who co-reviewed with Sarah Heuer

doi: 10.1016/j.cmet.2019.11.020 11 FreidmanNChenIWuQBriotCHolstJFontJet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Gurley B.J., Gardner S.F., Hubbard M.A., Williams D.K., Gentry W.B., Khan I.A., Shah A

NAD+ works as a co-substrate for several enzyme families: Sirtuins (SIRTs) : These NAD+-dependent deacetylases remove acetyl groups from proteins, including histones that affect gene expression and cellular function

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Connective tissue also suffers damage during the menopause because collagen production decreases and collagen breakdown accelerates