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[] Specifically, PGC-1 robustly stimulates mitochondrial biogenesis and respiratory function by inducing the expression of the NRF1 and NRF2

The lack of growth hormone receptor activation eliminates the concerning side effects associated with growth hormone therapy, and the peptides very short half-life prevents tissue accumulation

AOD-9604 works by stimulating lipolysis, the breakdown of stored fat, through beta-3 adrenergic receptors on fat cells

To understand the underlying molecular mechanisms, the expression levels of 3-AR mRNA in both white and brown adipose tissue were assessed using reverse transcription followed by PCR and Southern blotting