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"Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy." Bulletin of Experimental Biology and Medicine

Some small drugs - such as L-DOPA used to treat Parkinsons - can be ferried in on natural nutrient transport systems, but this approach has complications in finding the right dosing regime, as patients transporters have differing efficiencies

NAD+ (nicotinamide adenine dinucleotide), an essential coenzyme present in all living cells, activates sirtuins and supports DNA repair, mitochondrial function, and metabolic regulation -- touching multiple hallmarks simultaneously

In aged monkeys, pineal peptide preparations were similarly associated with changes in nocturnal melatonin release patterns and circadian amplitude measurements (7)