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In summary, MND-ART-GEL effectively triggered ICD and downregulated STAT3, thereby remodeling the immunosuppressive microenvironment of TNBC and eliciting a robust antitumor immune response in vivo

The SAM concentration is influenced by the folate cycle and the rest of one-carbon metabolism via the methionine synthase(MS) reaction that remethylates homocysteine to methionine

Furthermore, preclinical studies are investigating strategies to correct downstream pathologies common in sporadic ALS, such as targeting TDP-43 proteinopathy

Estrogen as a key regulator of energy homeostasis and metabolic health

Consistent with miR-30e-5p targeting SLC7A11 mRNA, ASO against miR-30e-5p increased OCR and decreased ECAR in ECs (Supplemental Figure 3C, 3D)