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The expression of CD38 is elevated in multiple tissues during aging, as well as in various inflammatory, autoimmune, degenerative, infectious and ischemic conditions and cancer 21

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Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

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Figure 2: Changes in the histolopathological scores amongst the four experimental treatment groups