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This review delineates the multidimensional mechanisms compromising Treg fitness, highlighting the loss of FoxP3 stability, aberrant expression of immune checkpoints (e.g., TIGIT and PD-1), and the skewing of the Th17/Treg axis as critical intrinsic drivers

Bioinformatics 32 (11), 17241732

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Zhang H, Wang M, He Y, Deng T, Liu R, Wang W, et al

FIGURE 1 Promotion of Homeostasis of Redox The synthesis of reactive oxygen species (ROS) and antioxidant glutathione (GSH) is essential in maintaining the redox balance in our body ( Promotion of Cell Proliferation The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) [PIK3/AKT/mTOR] pathway is one of the keys signaling pathways involved in cell proliferation ( Regulation of Autophagy Autophagy is an important process of intracellular turnover that is evolutionarily conserved in eukaryotes

Some forms of migraine are linked with one precise gene, for example hemiplegic migraine