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The most quantitatively striking effect reported in the Dihexa literature is on dendritic spine density in rat hippocampal neuron cultures

BPC-157 is acid-stable, so oral delivery is viable

In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

First-pass metabolism may be increased and oral bioavailability reduced through the induction of hepatic enzymes (e.g

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The peptide also exhibits neuroprotective properties and may facilitate neural regeneration through enhancement of axonal growth and synaptic plasticity