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Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway

References Gagner, J.E., Shrivastava, S., Qian, X., Dordick, J.S., and Siegel, R.W.: Engineering nanomaterials for biomedical applications requires understanding the nano-bio interface: A perspective

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