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Why the Combination is Needed: Combining glutathione, NAC, and Vitamin C enhances the overall antioxidant effect, providing better protection against oxidative damage and supporting liver detoxification

The cleaved N-terminal fragment of GSDME forms pores in the cell membrane, triggering pyroptosis, which is characterized by cell swelling, rupture, and the release of pro-inflammatory signals

Complex II deficiency was revealed in cultured skin fibroblasts and muscle from the first and second patients, respectively [30,31]

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*Correspondence: Sharmistha Dey, [email protected] ORCID: Sharmistha Dey, orcid.org/0000-0003-4122-7415 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

(b) Function of interleukins and TNF