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Pinero, J

Lancet Diabetes Endocrinol (2017) 5:597609

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Matrix metalloproteinase-2 mediates stretch-induced activation of skeletal muscle satellite cells in a nitric oxide-dependent manner

The N-terminal domain I is connected to the C-terminal domain II by a linker loop region consisting of around 10 amino acids [42, 62, 76]

Notably, patients with pre-existing conditions of obesity, hypertension, and diabetes have a less favorable disease outcome, likely in part due to the elevated levels of inflammation and metabolic disturbances associated with those conditions [25]