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In the tail suspension test (TST), the animals were hung on a bar for 6 minutes, and the immobility period, determined as the time displaying no motion, was recorded during the last 4 minutes

HDM-2 membrane overexpression has been confirmed across a wide range of cancer types in pre-clinical literature, including breast cancer, pancreatic cancer, ovarian cancer, lung cancer, colon cancer, cervical cancer, melanoma, osteosarcoma, and several haematological malignancies

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J Neurosci 36:80708077

Direct in vitro comparisons of these mAbs showed comparable antibody-dependent cell-mediated toxicity (ADCC) and binding affinities, but remarkable differences in the ability to induce direct apoptosis, to induce complement-mediated cytotoxicity (CDC), and to induce antibody-dependent cell-mediated phagocytosis (ADCP)

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