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This amplifies the ATF4/CHOP/ChaC1 cascade under ER stress, resulting in decreased intracellular GSH and cysteine, increased intracellular ROS, redox homeostasis disruption, secondary oxidative stress in cancer cells and selective ferroptosis of cancer cells (66,100)

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10.1155/2018/9390810 133 LiuY.DuanC.ChenH.WangC.LiuX.QiuM.et al (2018b)

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