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Mitochondrial dysfunction and deregulated nutrient sensing are central to aging (Lpez-Otn et al., 2013), with growing evidence of a bidirectional regulation between the circadian clock and metabolic pathways, particularly glucose metabolism and mTOR signaling (Khapre et al., 2014a

Additionally, the Papot group developed a prodrug by combining a galactoside trigger with a folate receptor (FR) ligand, resulting in the tubulin inhibitor monomethyl auristatin E (MMAE) release (Legigan et al., 2012)

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All five polyphenols have shown significant antioxidant activities, especially IQ (223)

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