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Neuromuscul Disord 2018;28:787-90

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Huang J, Jones DR, Altorki N, Antonoff MB , Blackmon S, Burt B, Demmy T, Evans N, Donohoe L, Jarrar D, Kozower B, Lanuti M, Liberman M, Lin J, Liou D, Liptay M, Luketich J, Pennathur A, Petersen G, Ripley R, Rochefort M, Seder CW, Shrager J, Su S, Tong B, Shargall Y, Waddell T, Weksler B, Wigle D, Yendamuri S, Bueno R, Harpole D

Respirable Output: Mass of respirable particles produced per minute (aerosol output - respirable fraction) Tidal Breathing: Normal steady breathing

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Previous efforts to prospectively discover monovalent degraders have identified minimal electrophilic groups that can be appended onto pre-existing ligands to yield active degraders 25,26