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The retina is especially vulnerable to oxidative stress due to its high oxygen exposure and high concentration of polyunsaturated fatty acids

Certain retained components of various cell death pathways such as Fas (CD95)/Fas ligand (FasL, CD95L) signaling, caspase-3, caspase-8, or RIPK1/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain like pseudokinase) axis can be considered a heritage of the erythroid lineage cells

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and 2) cancer cells exhibit a spectrum of sensitivity to glucose deprivation 12