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The effectiveness of LXB, a sleep-inducing treatment, on idiopathic hypersomnia symptoms suggests altered sleep architecture may contribute to this disorder

Interestingly, SKN-1/Nrf2 has more recently been connected to amino acid and lipid metabolism during starvation

Iritani S, Imai K, Takai K, et al

Both of these effects were canceled in the presence of an antagonist of melanocortin receptors 3 and 4, confirming receptor-mediated mechanisms

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Benzodiazepine pharmacology and central nervous system-mediated effects