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Clinical translation of the developed PLGA-based nanosystems encapsulating conventional drugs and/or bioactive phytochemicals remains a challenge due to limited clinical trials validating the safety and efficacy of PLGA nano-systems

Future research should prioritize personalized VNS therapies, leveraging closed-loop systems integrated with multimodal biomarkers (e.g., EEG-gated taVNS) to dynamically optimize stimulation in real-time (123)

GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Long-term use of NSAIDs may lead to side effects on the cardiovascular system, gastrointestinal tract, and kidneys, such as increased risks of heart disease, indigestion, gastrointestinal ulcers, bleeding, and reduced kidney function

Persistent symptoms should trigger a review of dose, hydration, sleep, and product quality

In addition, when lipids accumulate in DC, the antigen presenting function of DC is impaired, which further leads to the impairment of T cell response and anti-tumor immunity