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That is worth being honest with yourself about, and it is still clinically useful

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The Que-Exo group had significantly less proteoglycan loss compared to the Normal saline and Exo groups, indicating that Que-Exo treatment helped maintain cartilage structure and function

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The supernatant was centrifuged (3,000 g /30 min/4 C) and new supernatant filtered through a 0.22 m pore size filter before centrifugation (25,000 g /30 min/4 C) and final centrifugation (100,000 g /60 min/4 C) with a final wash in 0.22 m pore-filtered PBS, re-centrifugation and resuspension in a minimal volume

It will explain why obvious signs like cognitive decline and fatigue are often mistaken for normal aging, even by healthcare professionals