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The cCPP-CeNPs group exhibited a significant restoration of cell viability, while minimal effect was observed in the PEG-CeNPs or lCPP-CeNPs groups (Fig

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Therefore, TMD6 and TMD7 helices of TAS1R3 are integral to allosteric modulation of the sweet receptor, implicating them in TAS1R2 and TAS1R3 subunit interactions and indicating an important role for this structural region in the conformational changes involved in receptor activation