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However, factors such as advanced aging, peripheral inflammation, and cerebral amyloid angiopathy can compromise the integrity of the BBB [182, 183]

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Such heterogeneity is a likely determinant of outcome and is considered a major barrier to developing or optimizing therapeutics for the brain-injured patient (Saatman et al., 2008)

133 (2), 199e207e (2014) Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., et al.: Oxidative stress: harms and benefits for human health