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However, many factors, including their low stability, short half-life, high immunogenicity, tissue targeting, cellular uptake, and endosomal escape, hamper the delivery and clinical application of NADs

The number of anticodons present in the anticodon arm is increased to 4 (UCCA) to match the corresponding 4-letter codon (AGGU)

The disrupted homeostasis of the Glu-Gln cycle caused by astrocyte-specific Glu transporter (GLT1) deficiency was reported to induce pathological repetitive behaviors

Sci Rep 10(1):2259 Lora J, Alonso FJ, Segura JA, Lobo C, Mrquez J, Mats JM (2004) Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells

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