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The enzyme catalyses a one-electron as well as a two-electron reduction of oxygen to form O 2 or H 2 O 2 , with itself being converted to uric acid [12]

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Furthermore, combination therapy with disulfiram and conventional chemotherapeutic agents (e.g., PARP inhibitors, sorafenib, doxorubicin) has demonstrated synergistic effects in vitro and in animal models, partially overcoming tumor resistance and improving therapeutic efficacy (70, 72, 73)

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For non-randomized studies, including cohort and casecontrol studies, the Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool (Sterne et al., 2016) was employed to assess methodological quality across seven key domains: (1) bias due to confounding, (2) bias due to selection of participants, (3) bias in classification of interventions, (4) bias due to deviations from intended interventions, (5) bias due to missing data, (6) bias in measurement of outcomes, and (7) bias in selection of the reported result

[DOI] [PubMed] [Google Scholar] 3.Steinmann B., Royce P.M., Superti-Furga A