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[DOI] [PMC free article] [PubMed] [Google Scholar] 143.Mambrini S.P., Grillo A., Colosimo S., Zarpellon F., Pozzi G., Furlan D., Amodeo G., Bertoli S

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Linkers typically comprise a direct bond or an atom such as oxygen or sulfur, a unit such as NR 1 , C(O), C(O)NH, SO, SO 2 , SO 2 NH or a chain of atoms, such as substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkenyl, alkylarylalkyl, alkylarylalkenyl, alkylarylalkynyl, alkenyl the linker is [(P-Q-R) q X(P-Q-R) q ] q -T-, wherein: P, R, T, P, R and T are each independently for each occurrence absent, CO, NH, O, S, OC(O), NHC(O), CH 2 , CH 2 NH, CH 2 O

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They also proved that treatment of mice with DON led to glutamine accumulation, indicating that DON was able to inhibit glutamine metabolism in AML cells [54]