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Intriguingly however, disruption of Fe-S cluster biogenesis by cysteine deprivation in ovarian clear cell carcinoma cell lines only led to ferroptotic cell death in cells which were relying more heavily on glycolysis for energy production ( Previous work indicates that in addition to the control of IRP1 function, IRP2 stability is also dependent upon Fe-S cluster assembly proteins (Stehling et al., 2013), but this has only recently been explored in the context of ferroptosis (Terzi et al., 2021)

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Liu RY, Corry PM, Lee YJ (1995) Potential involvement of a constitutive heat shock element binding factor in regulating chemical stress-induced hsp70 gene expression

Bhat, Aligarh Muslim University, India Reviewed by Mumtaz Anwar, University of Illinois at Chicago, United States Samirul Bashir, University of Massachusetts Medical School, United States Updates Copyright 2022 Bhat, Akther, Najar, Rasool and Hamid